登记号
CTR20192156
相关登记号
CTR20191511,CTR20192153
曾用名
药物类型
生物制品
临床申请受理号
企业选择不公示
适应症
活动性溃疡性结肠炎
试验通俗题目
评价 LY3074828 用于活动性溃疡性结肠炎患者的维持期研究
试验专业题目
一项评价LY3074828用于中度至重度活动性溃疡性结肠炎患者的3期、多中心、随机、双盲、平行组、安慰剂对照的维持期研究
试验方案编号
I6T-MC-AMBG； 2018年3月13日
方案最近版本号
16T-MC-AMBG（12.1)
版本日期
2022-08-23
方案是否为联合用药
企业选择不公示
申请人信息
申请人名称
联系人姓名
康晓倩
联系人座机
23021428
联系人手机号
联系人Email
kang_xiao_qian@lilly.com
联系人邮政地址
上海市-上海市-上海市静安区石门一路288号香港兴业太古汇1座19楼
联系人邮编
200041
临床试验信息
试验分类
安全性和有效性
试验分期
III期
试验目的
评估完成前12周诱导研究AMAN的参与者使用LY3074828维持治疗的有效性和安全性
随机化
随机化
盲法
双盲
试验范围
国际多中心试验
设计类型
平行分组
年龄
18岁(最小年龄)至
80岁(最大年龄)
性别
男+女
健康受试者
无
入选标准
- 已完成了AMAN研究，接受至少1次研究药物给药且未提前结束研究药物给药
- 愿意且能够完成计划的研究评估，包括内镜检查和每日日志录入
- 如果是女性，必须符合避孕要求
排除标准
- 在此前诱导期研究AMAN期间诊断为克罗恩病或炎症性肠病 – 未分类（结肠炎）
- 在此前诱导期研究AMAN期间接受肠切除术或其他手术来治疗UC，或在AMBG研究期间可能需要接受手术来治疗UC
- 在研究AMAN期间存在结肠不典型增生或诊断为胃肠道癌
- 在诱导期研究AMAN期间诊断为有临床意义的感染，包括但不限于乙型肝炎、丙型肝炎、HIV/AIDS和活动性结核（TB）
- 在诱导期研究AMAN期间开始新的禁止使用的药物治疗
- 在开始AMBG研究之前存在某些实验室异常，且需要永久终止研究药物治疗
试验分组
试验药
| 名称 | 用法 |
|---|---|
|
中文通用名:LY3074828注射液 预填充式注射器
|
用法用量:注射液，规格100mg/ml，皮下给药；对于应答组患者，每四周一次200mg皮下注射，用药时程最长40周，在12-28周之间，如确认患者失去应答，则给予每四周一次LY3074828 300 mg输注给药12周，对于非应答组患者将接受开放标签LY3074828每四周一次 300 mg输注给药12周，如果患者应答将继续给予患者LY3074828 每四周一次200mg皮下给药28周，如不应答则退出试验
|
|
中文通用名:LY3074828注射液 小瓶
|
用法用量:注射液，规格20mg/ml，输注给药；对于应答组患者，每四周一次200mg皮下注射，用药时程最长40周，在12-28周之间，如确认患者失去应答，则给予每四周一次LY3074828 300 mg输注给药12周，对于非应答组患者将接受开放标签LY3074828每四周一次 300 mg输注给药12周，如果患者应答将继续给予患者LY3074828 每四周一次200mg皮下给药28周，如不应答则退出试验
|
对照药
| 名称 | 用法 |
|---|---|
|
中文通用名:外形与LY3074828注射液相同的安慰剂 预填充式注射器
|
用法用量:注射液，规格100mg/ml，皮下给药；对于应答组患者，每四周一次200mg皮下注射，用药时程最长40周，在12-28周之间，如确认患者失去应答，则给予每四周一次LY3074828 300 mg输注给药12周，对于非应答组患者将接受开放标签LY3074828每四周一次 300 mg输注给药12周，如果患者应答将继续给予患者LY3074828 每四周一次200mg皮下给药28周，如不应答则退出试验
|
|
中文通用名:外形与LY3074828注射液相同的安慰剂 预填充式注射器
|
剂型:注射液
|
终点指标
主要终点指标
| 指标 | 评价时间 | 终点指标选择 |
|---|---|---|
| 临床缓解状态的患者比例，临床缓解基于改良的Mayo评分（MMS） | 第40周 | 有效性指标+安全性指标 |
次要终点指标
| 指标 | 评价时间 | 终点指标选择 |
|---|---|---|
| 企业选择不公示 |
数据安全监察委员会（DMC）
有
为受试者购买试验伤害保险
研究者信息
| 姓名 | 学位 | 职称 | 电话 | 邮政地址 | 邮编 | 单位名称 | |
|---|---|---|---|---|---|---|---|
| 冉志华 | 博士 | 教授 | 021-58752345 | zhihuaran@vip.163.com | 上海市-上海市-上海市东方路1630号 | 200127 | 上海交通大学医学院附属仁济医院 |
| 沈骏 | 博士 | 主任医师 | 021-58752345 | shenjun@vip.163.com | 上海市-上海市-上海市东方路1630号 | 200127 | 上海交通大学医学院附属仁济医院 |
各参加机构信息
| 机构名称 | （主要）研究者 | 国家 | 地区 | 城市 |
|---|---|---|---|---|
| 上海交通大学医学院附属仁济医院 | 冉志华 | 中国 | 上海市 | 上海市 |
| 上海交通大学医学院附属仁济医院 | 沈骏 | 中国 | 上海市 | 上海市 |
| 浙江大学医学院附属邵逸夫医院 | 曹倩 | 中国 | 浙江 | 杭州 |
| 中山大学附属第六医院 | 高翔 | 中国 | 广东 | 广州 |
| 华中科技大学同济医学院附属同济医院 | 刘梅 | 中国 | 湖北 | 武汉 |
| 江苏省人民医院 | 张国新 | 中国 | 江苏 | 南京 |
| 上海交通大学医学院附属瑞金医院 | 钟捷 | 中国 | 上海 | 上海 |
| 安徽省立医院 | 张开光 | 中国 | 安徽 | 合肥 |
| 中南大学湘雅医院 | 徐美华 | 中国 | 湖南 | 长沙 |
| 温州医科大学第二附属医院 | 蒋益 | 中国 | 浙江 | 温州 |
| 陆军军医大学第二附属医院 | 郭红 | 中国 | 重庆 | 重庆 |
| 山东大学齐鲁医院 | 李延青 | 中国 | 山东 | 济南 |
| 聊城市人民医院 | 焉鹏 | 中国 | 山东 | 聊城 |
| 昆明医科大学第一附属医院 | 张海蓉 | 中国 | 云南 | 昆明 |
| 浙江大学医学院附属第二医院 | 陈焰 | 中国 | 浙江 | 杭州 |
| 东南大学附属中大医院 | 施瑞华 | 中国 | 江苏 | 南京 |
| 安徽医科大学第一附属医院 | 胡乃中 | 中国 | 安徽 | 合肥 |
| 陆军军医大学第一附属医院（重庆西南医院） | 陈磊 | 中国 | 重庆 | 重庆 |
| 华中科技大学同济医学院附属协和医院 | 侯晓华 | 中国 | 湖北 | 武汉 |
| 南京鼓楼医院 | 邹晓平 | 中国 | 江苏 | 南京 |
| 云南省第一人民医院 | 宋正己 | 中国 | 云南 | 昆明 |
| 海南省人民医院 | 蓝程 | 中国 | 海南 | 海口 |
| 江西萍乡市人民医院 | 李兴 | 中国 | 江西 | 萍乡 |
| 浙江大学第一附属医院 | 陈春晓 | 中国 | 浙江 | 杭州 |
| 南京市江宁医院 | 王建宁 | 中国 | 江苏 | 南京 |
| 吉林市中心医院 | 王东明 | 中国 | 吉林省 | 吉林市 |
| 四川大学华西医院 | 王玉芳 | 中国 | 四川省 | 成都市 |
| 武汉大学人民医院 | 丁一娟 | 中国 | 湖北省 | 武汉市 |
| 常州市第二人民医院 | 刘文佳 | 中国 | 江苏省 | 常州市 |
| 泰安市中心医院 | 王庆才 | 中国 | 山东省 | 泰安市 |
| 株洲市中心医院 | 吴达军 | 中国 | 湖南省 | 株洲市 |
| 青岛大学附属医院 | 丁雪丽 | 中国 | 山东省 | 青岛市 |
| 山东省立医院（东院区） | 刘吉勇 | 中国 | 山东省 | 济南市 |
| 南昌大学第一附属医院 | 陈幼祥 | 中国 | 江西省 | 南昌市 |
| 福建医科大学附属第一医院 | 王承党 | 中国 | 福建省 | 福州市 |
| 郑州大学第二附属医院 | 冯百岁 | 中国 | 河南省 | 郑州市 |
| 河北医科大学第二医院 | 张晓岚 | 中国 | 河北省 | 石家庄市 |
| 山东省立医院（中心院区） | 刘吉勇 | 中国 | 山东省 | 济南市 |
| 中国医科大学附属盛京医院滑翔院区 | 郑长清 | 中国 | 辽宁省 | 沈阳市 |
| Universit？tsklinikum Salzburg | Sonja Gassner | Austria | Salzburg | Salzburg |
| Medical University of Vienna | Walter Reinisch | Austria | Vienna | Vienna |
| Medizinische Universit？t Innsbruck | Robert Koch | Austria | Tyrol | Innsbruck |
| Universitaire Ziekenhuizen Leuven - Campus Gasthuisberg | Marc Ferrante | Belgium | Flemish Brabant | Leuven |
| AZ Klina | Jos Callens | Belgium | Antwerp | Brasschaat |
| Universitair Ziekenhuis Gent | Pieter Hindryckx | Belgium | East Flanders | Gent Oost-Vlaanderen |
| Centre Hospitalier de Wallonie | Souhail Saikali | Belgium | Hainaut | Tournai |
| ISCARE Clinical Centre | Milan Lukas | Czech Republic | Praha | Praha |
| Hepato-gastroenterologie HK, s.r.o. | Miroslava Volfova | Czech Republic | Královéhradecky | Hradec Kralove |
| PreventaMed, s.r.o. | Jiri Pumprla | Czech Republic | Olomoucky | Olomouc |
| Fakultni nemocnice Kralovske Vinohrady | Zdena Zadorova | Czech Republic | Praha | Praha |
| Mediendo s.r.o. | Stepan Suchanek | Czech Republic | Praha | Praha |
| A-Shine s.r.o. | Lubos Janu | Czech Republic | Plzeňsky | Plzen |
| Fakultni nemocnice u sv. Anny v Brne | Jan Ulbrych | Czech Republic | South Moravian | Brno |
| Gregar s.r.o. | Jan Gregar | Czech Republic | Olomoucky | Olomouc |
| Vojenska nemocnice Brno | Tomas Brabec | Czech Republic | South Moravian | Brno |
| Zealand University Hospital K？ge | Signe Wildt | Denmark | Sj？lland | K？ge |
| Herlev and Gentofte Hospital | Jakob Seidelin | Denmark | Hovedstaden | Herlev |
| Hopital de Hautepierre - Service d’Hépatogastroentérolgie | Jean-Marie Reimund | France | Strasbourg Cedex Bas Rhin | Strasbourg Cedex Bas Rhin |
| Hopital Saint Eloi | Romain Altwegg | France | Hérault | Montpellier |
| CHU Tours - H？pital Trousseau | Laurence Picon | France | Indre-et-Loire | Chambray les Tours |
| Hopital Saint-Louis | Matthieu Allez | France | Paris Cedex | Paris Cedex |
| Hopital Beaujon | Xavier Treton | France | Hauts-de-Seine | Clichy |
| CHU Amiens Picardie-Site Sud - RDC Service Hépato gastro | Mathurin Fumery | France | Somme | Amiens Cedex |
| CHU de Saint Etienne Hopital Nord Avenue Albert Raimond | Xavier Roblin | France | Loire | Saint Priest en Jarez France |
| Hospices Civils de Lyon - Centre Hospitalier Lyon Sud - | Stephane Nancey | France | Pierre Benite cedex Rhone | Pierre Benite cedex Rhone |
| Centre Hospitalier de Pau 4 BD Hauterive | Mireille Simon | France | Pau CEDEX | Pau CEDEX |
| ROBERT DEBRE HOSPITAL AVENUE DU GENERAL | Guilllaume Cadiot | France | REIMS | REIMS |
| Hopital L'Archet 2 | Xavier Hebuterne | France | Nice Cedex | Nice Cedex |
| CHU Lille - H？pital Claude Huriez | Pierre Desreumaux | France | Lille cedex Nord | Lille cedex Nord |
| CHRU Nancy Brabois - H？pital d'Enfants | Laurent Peyrin-Biroulet | France | Vandoeuvre les Nancy | Vandoeuvre les Nancy |
| Hopital Nord de Marseille | Jean-Charles Grimaud | France | Marseille Cedex | Marseille Cedex |
| CHU Bordeaux - H？pital Haut-Lévêque | David Laharie | France | Pessac Cedex | Pessac Cedex |
| INLUGA im Haus der Gesundheit | Peter Uebel | Germany | Rhineland-Palatinate | Ludwigshafen |
| Krankenhaus Waldfriede e. V. | Carsten Buening | Germany | Berlin | Berlin |
| Staedisches Klinikum Brandenburg | Stefan Lueth | Germany | Brandenburg | Brandenburg |
| Internistische Praxisgemeinschaft | Vassilios Kardalinos | Germany | Lower Saxony | Weyhe |
| Medizinische Hochschule Hanover Abt. Gastroenterologie, Geb？ude | Ursula Seidler | Germany | Niedersachsen | Hannover Niedersachsen |
| Studiengesellschaft BSF Unternehmergesellschaft haftungsbeschraenkt | Lars Fechner | Germany | Sachsen-Anhalt | Halle (Saale) |
| Martin-Luther-Universit？t Halle-Wittenberg | Jens Walldorf | Germany | Sachsen-Anhalt | Halle (Saale) |
| Charité Universit？tsmedizin Berlin Campus Buch | Britta Siegmund | Germany | Berlin Berlin | Berlin Berlin |
| Hamburgisches Forschungsinstitut fuer Chronisch Entzuendliche Darmerkrankungen | Stefanie Howaldt | Germany | Hamburg | Hamburg |
| Endomedix Diagnosztikai Kozpont | Tunde Kristof | Hungary | Borsod-Abaúj-Zemplén | Miskolc |
| Semmelweis Egyetem II.sz. Belgyogyaszati Klinika | Zsolt Tulassay | Hungary | Budapest | Budapest |
| Clinfan Szolgaltato Kft. | Agnes Salamon | Hungary | Tolna megye | Szekszard |
| Obudai Egeszsegugyi Centrum Kft | Csaba Fulop | Hungary | Budapest | Budapest |
| Debreceni Egyetem Klinikai Kozpont | Istvan Altorjay | Hungary | Hajdú-Bihar | Debrecen |
| DRC Gyogyszervizsgalo Kozpont Kft. | Laszlo Koranyi | Hungary | Veszprém | Balatonfüred EU |
| Karolina Korhaz-Rendelointezet | Gyula Pecsi | Hungary | Gy？r-Moson-Sopron megye | Mosonmagyarovar |
| Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont I. Belgyogyaszati Klinika | Tamas Molnar | Hungary | Csongrád-Csanád megye | Szeged |
| Javorszky Odon Hospital | Tibor Szaloki | Hungary | Pest megye | Vac |
| Beaumont Hospital | Aoibhlinn O'Toole | Ireland | Dublin | Dublin |
| Presidio di Rho | Simone Saibeni | Italy | Milan | Rho Milano |
| Azienda Ospedaliero Universitaria San Martino | Maria Caterina Parodi | Italy | Liguria | Genova Genova |
| Azienda Ospedaliera Universitaria Pisana | Santino Marchi | Italy | Tuscany | Pisa |
| Azienda Ospedaliera Universitaria Policlinico Tor Vergata | Giovanni Monteleone | Italy | Milan | San Donato Milanese |
| Istituto Clinico Humanitas | Silvio Danese | Italy | Milan | Rozzano Milano |
| Policlinico Univ. Agostino Gemelli | Antonio Gasbarrini | Italy | Lombardy | Roma |
| I.R.C.C.S Policlinico San Donato | Luca Pastorelli | Italy | Milan | Donato Milanese |
| Gastroenterology and Endoscopy Unit IRCCS Ca’ Granda Ospedale Maggiore Policlinico Foundation | Maurizio Vecchi | Italy | Lombardy | Milano |
| Azienda Ospedaliero-Universitaria Santa Maria della Misericordia Gastroenterologia | Marco Marino | Italy | Friuli-Venezia Giulia | Udine |
| Azienda ospedaliero-universitaria Mater Domini | Francesco Luzza | Italy | Catanzaro | Catanzaro |
| Ospedale Mauriziano Umberto I | Marco Daperno | Italy | Piedmont | Torino |
| Ospedale Sandro Pertini | Roberta Pica | Italy | Lazio | Roma |
| Azienda Ospedaliera Universitaria Policlinico de Modena | Erica Villa | Italy | Emilia-Romagna | Modena |
| Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili) | Chiara Ricci | Italy | Lombardy | Brescia |
| Digestive Diseases Center | Ivars Tolmanis | Latvia | Riga | Riga |
| Pauls Stradins Kliniska Universitates Slimnica | Juris Pokrotnieks | Latvia | Riga | Riga |
| Riga Eastern Clinical University Hospital | Ateksejs Derovs | Latvia | Riga | Riga |
| Republic Hospital of Klaipeda | Arunas Kancauskas | Lithuania | Klaipeda | Klaipeda |
| Klaipeda Seamen's Hospital | Giedrius Simulionis | Lithuania | Klaipeda | Klaipeda |
| Vilnius University Hospital Santariskiu Clinics | Ieva Stundiene | Lithuania | Vilnius | Vilnius |
| Respublikine Panevezio Ligonine | Darius Kriukas | Lithuania | Panevezys | Panevezys |
| Hospital of Lithuanian University of Health Sciences Kaunas | Gediminas Kiudelis | Lithuania | Kaunas | Kaunas |
| St Elisabeth Ziekenhuis | Robert Laheij | Netherlands | Brabant | Tilburg |
| Bernhoven Ziekenhuis Researchbureau MDL | Ingrid Gisbertz | Netherlands | Brabant | Uden |
| UMC Utrecht, Dept. of Internal Medicine, MDL | Herma Fidder | Netherlands | Utrecht | Heidelberglaan |
| Academisch Medisch Centrum | Mark Lowenberg | Netherlands | North Holland | Alkmaar Zaanstreek |
| Niepubliczny Zaklad Opieki Zdrowotnej SONOMED | Anna Wiechowska-Kozlowska | Poland | Pomeranian | Szczecin |
| PlanetMed Sp.z o.o. | Barbara Wozniak-Stolarska | Poland | Lower Silesian | Wroclaw |
| Samodzielny Publiczny Szpital Kliniczny nr 4 | Cichoz-Lach Halina | Poland | Lublin | Lublin |
| Centrum Zdrowia Matki, Dziecka i M？odzie？y (CZMDM) Przychodnie | Michal Lawinski | Poland | Mazovia | Warszawa |
| Twoja Przychodnia-Szczecinskie Centrum Medyczne | Beata Gawdis-Wojnarska | Poland | West Pomeranian | Szczecin |
| NZOZ ALL-MEDICUS, Zaklad Gastroenterologii | Aldona Mularczyk | Poland | Silesian | Katowice |
| PROMEDICA S.C | Lukasz Firkowski | Poland | Silesian | Bedzin |
| KO-MED Centra Kliniczne Staszow | Jacek Kieltucki | Poland | ？wi？tokrzyskie | Staszow |
| Centrum Medyczne NeuroProtect | Maciej Gonciarz | Poland | Masovian | Warszawa |
| Wojewodzki Specjalistyczny Szpital w Olsztynie | Tomasz Arlukowicz | Poland | Warmian-Masurian | Olsztyn |
| ETG Zamosc | Katarzyna Wojcik | Poland | Lublin | Zamosc |
| GASTROMED KOPO？ ZMUDZI？SKI I WSPóLNICY SPó？KA JAWNA SPECJALISTYCZNE CENTRUM GASTROLOGII I ENDOSKOPII | Marcin Zmudzinski | Poland | Kuyavian-Pomeranian | Torun |
| Topolowa Medicenter | Zbigniew Wylegala | Poland | Lesser Poland | Krakow |
| NZOZ FORMED | Beata Mroziak | Poland | Lesser Poland | Wadowice |
| Medicenter Nowy Targ | Przemyslaw Zycinski | Poland | Lesser Poland | Nowy Targ |
| Warsaw IBD Point Profesor Kierkus | Jaroslaw Kierkus | Poland | Masovian | Warszawa |
| Szpital Uniwersytecki Nr 2 im. dr J. Biziela w Bydgoszczy, Klinika Reumatologii i Chorob Tkanki Lacznej | Maria Klopocka | Poland | Kuyavian-Pomeranian | Bydgoszcz |
| Vivamed | Robert Petryka | Poland | Masovian | Warszawa |
| LexMedica Osrodek Badan Klinicznych | Jerzy Rozciecha | Poland | Lower Silesian | Wroclaw |
| GASTROMED Zak？ad Opieki Zdrowotnej | Wit Danilkiewicz | Poland | Lublin | Lublin |
| Hifu Terramed Conformal SRL | Theodor-Alexandru Voiosu | Romania | Ilfov | Bucuresti |
| CCBR Clinical Research | Daniela Bartos | Romania | Ilfov | Bucuresti |
| MedLife Grivita | Ion-Eugeniu Craciun | Romania | Ilfov | Bucuresti |
| Spitalul Clinic Colentina | Radu Mateescu | Romania | Ilfov | Bucuresti |
| Spital Pelican Oradea | Alin-Horea Suta | Romania | Bihor | Oradea |
| Institutul Clinic Fundeni | George Stancu | Romania | Ilfov | Bucuresti |
| Fakultna nemocnica s poliklinikou Roosevelta Banska Bystrica | Jozef Balaz | Slovakia | Banska | Bystrica |
| Gastro I s.r.o., Gastroenterologická ambulancia | Ivan Bunganic | Slovakia | Pre？ov | Pre？ov |
| Endomed, s.r.o.- Gastroenterologicka ambulancia | Miroslav Fedurco | Slovakia | Pre？ov | Vranov n. Toplou |
| KM Management spol. s r.o. Gastroenterologicke a hepatologicke centrum | Milos Gregus | Slovakia | Nitra | Nitra |
| Univerzitna nemocnica Bratislava Cliniq s.r.o. Gastroenterologicka ambulancia | Tibor Hlavaty | Slovakia | Bratislava | Bratislava |
| Hospital Universitari de Girona | Xavier Aldeguer Mante | Spain | Girona | Girona |
| Hospital Universitario Marques De Valdecilla | Javier Crespo Garcia | Spain | Cantabria | Santander |
| Hospital General Juan Ramón Jiménez | Juan Maria Vazquez Moron | Spain | HUELVA | HUELVA |
| Complexo Hospitalario Universitario A Coru？a, CHUAC | Maria Teresa Diz-Lois Palomares | Spain | La Coru？a | La Coru？a |
| Hospital De Fuenlabrada | Fernando Bermejo San Jose | Spain | Madrid | Fuenlabrada |
| INSTITUTO DE CIENCIAS MéDICAS | Luis De Teresa Parreno | Spain | Valencian | Alicante |
| Hospital Universitario La Paz Unidad de Enfermedad | Maria Dolores Martin Arranz | Spain | Madrid | Madrid |
| Hospital de Sagunto | Xavier Cortes Rizo | Spain | Valencia | Port de Sagunto |
| HOSPITAL UNIVERSITARIO VIRGEN DEL ROCIO | Eduardo Leo Carnerero | Spain | Andalucía | Sevilla |
| Hospital Universitario Central de Asturias | Sabino Riestra Menendez | Spain | Asturias | Oviedo |
| Hospital De Gran Canaria Dr. Negrin | Daniel Ceballos Santos | Spain | Canary | Las Palmas de Gran Canaria |
| Hospital Universitari Son Espases | Daniel Ginard Vicens | Spain | Balearic | Palma de Mallorca |
| Universit？tsspital Zürich USZ Zürich | Luc Biedermann | Switzerland | Zürich | Zürich |
| Kantonsspital St.Gallen Studienabteilung Gastroenterologie | Stephan Brand | Switzerland | St. Gallen | St.Gallen |
| Inselspital Bern | Pascal Juillerat | Switzerland | Bern | Bern |
| Praxis Balsiger, Seibold & Partner und Crohn-Colitis-Zentrum | Frank Seibold | Switzerland | Bern | Bern |
| Fairfield General Hospital | Jimmy Limdi | United Kingdom | Lancashire | Bury |
| St James's University Hospital Leeds Cardiovascular and Metabolic Medicine (LICAMM) | Christian Selinger | United Kingdom | West Yorkshire | Leeds |
| Morriston Hospital | Mesbah Rahman | United Kingdom | Swansea | Swansea |
| Queens Hospital | Leena Sinha | United Kingdom | Essex | Romford |
| St Thomas' Hospital | Peter Irving | United Kingdom | London | London |
| Whipps Cross University Hospital | Syed Hoque | United Kingdom | London | London |
| Hopital Maisonneure-Rosemount | Guy Aumais | Canada | Quebec | Montreal |
| Inflammatory Bowel Disease Centre Montreal General Hospital - MUHC | Waqqas Afif | Canada | Quebec | Montreal |
| University of Western Ontario | Vipul Jairath | Canada | Ontario | London |
| Allen Whey Khye Lim Professional Corporation | Allen Lim | Canada | Alberta | Edmonton |
| The Gordon and Leslie Diamond Health Care Centre | Baljinder Salh | Canada | British Columbia | Vancouver |
| Victoria Hospital | Terry Ponich | Canada | ONTARIO | LONDON |
| GI Research Institute | Gregory Rosenfeld | Canada | British Columbia | Vancouver |
| PerCuro Clinical Research Ltd. | Dustin Loomes | Canada | British Columbia | Victoria |
| Centre de santé et de services sociaux Champlain-Charles-Le Moyne | Etienne Desilets | Canada | Park Quebec | Greenfield |
| Texas Digestive Disease Consultants | Timothy Ritter | United States | Ontario | Southlake |
| Minnesota Gastroenterology, P.A. | Daniel Van Handel | United States | Devon | Plymouth |
| Maricopa Integrated Health System | Keng-Yu Chuang | United States | Arizona | Phoenix |
| Digestive Disease Associates, Ltd. | Nirav Shah | United States | Pennsylvania | Wyomissing |
| Wellness Clinical Research | Lucky Flores | United States | Florida | Hialeah |
| Clinical Research Institute of Michigan, LLC | Ronald Fogel | United States | Michigan | Chesterfield |
| Digestive Healthcare of Georgia | Michael Galambos | United States | Georgia | Atlanta |
| Emeritas Research Group | Satinder Gill | United States | Virginia | Leesburg |
| Digestive Health Associates of Texas | Harry Sarles | United States | Texas | Garland |
| Carolina Digestive Diseases | Phillip Goldstein | United States | North Carolina | Greenville |
| Northwell Health | Keith Sultan | United States | New York | Great Neck |
| Paramount Medical Research | Mazen Issa | United States | Ohio | Middleburg Heights |
| Weill Cornell Medical College | Ellen Scherl | United States | New York | New York |
| Gastro One | Ziad Younes | United States | Tennessee | Germantown |
| Huron Gastroenterology Associates | Najm Soofi | United States | Michigan | Ypsilanti MI |
| Biopharma Informatic, LLC | James Maher | United States | Texas | Houston |
| University of Oklahoma Health Sciences Center | Richard Harty | United States | Oklahoma | Oklahoma City |
| Research Associates of South Florida, LLC | Javier Sobrado | United States | Florida | Miami |
| Carilion Clinic Gastroenterology | Maithili Chitnavis | United States | Virginia | Roanoke |
| Henry Ford Health System Gastroenterology/Hepatology | Nirmal Kaur | United States | Michigan | Novi |
| Grand Teton Research Group, PLLC | Clint Behrend | United States | Idaho | Idaho Falls |
| UCSF Medical Center at Mission Bay | Melvin Heyman | United States | California | San Francisco |
| Southern Star Research Institute, LLC | Jeff Bullock | United States | Texas | San Antonio |
| Nola Research Works, LLC | Vivek Huilgol | United States | Louisiana | New Orleans |
| Midwest Medical Care | Chandar Singaram | United States | South Dakota | Sioux Falls |
| California Medical Research Group | Calin Arimie | United States | California | Northridge |
| DCR-PI, PC | Connie Hsu | United States | Arizona | Litchfield Park |
| Care Access Research | Mark Kogan | United States | California | Berkeley |
| Gastroenterology Research of San Antonio | Nicholas Martinez | United States | Texas | San Antonio |
| Nature Coast Clinical Research, LLC | Paul Hellstern | United States | Florida | Inverness |
| Central Sooner Research | Robert Gordon | United States | Oklahoma | Norman |
| Gastroenterology Associates of Pensacola, PA | Frederic Newman | United States | Florida | Pensacola |
| Indiana University School of Medicine | Sashidhar Sagi | United States | Indiana | Indianapolis |
| Wisconsin Center for Advanced Research | Brian Moloney | United States | Wisconsin | Milwaukee |
| University of North Carolina | Animesh Jain | United States | North Carolina | Chapel Hill |
| Digestive Health Specialists of the Southeast | Paul Lamb | United States | Alabama | Dothan |
| Florida Hospital | Udayakumar Navaneethan | United States | Florida | Orlando |
| Clinical Applications Laboratories, Inc | Vijayalakshmi Pratha | United States | California | San Diego |
| Om Research, LLC | Jatinder Pruthi | United States | California | Lancaster |
| Cotton-O'Neil Clinical Research Center, Digestive Health | Curtis Baum | United States | Kansas | Topeka |
| Gastroenterology Associates of Western Michigan, P.L.C. | Allan Coates | United States | Michigan | Wyoming |
| NorthShore University HealthSystem | Eugene Yen | United States | Illinois | Evanston |
| Physicians Research Group | Doo-Sang Cho | United States | Arizona | Tempe |
| Care Access Research LLC - Salt Lake City | Chad Gonzales | United States | Utah | Ogden |
| Care Access Research LLC | Glenn Freed | United States | Pennsylvania | Pottsville |
| Texas Digestive Disease Consultants | Timothy Ritter | United States | Texas | Southlake |
| Care Access Research - Youngstown | Sayed Yossef | United States | Ohio | Poland OH |
| Texas Digestive Disease Consultants | Jonathon Chapman | United States | Louisiana | Baton Rouge |
| Valley Gastroenterology Cnslts | Elias Tarakji | United States | California | Arcadia |
| Houston Methodist Research Ins | Bincy Abraham | United States | Texas | Houston |
| The Gasteroenterology Group, PC | Emil Valle | United States | Virginia | Reston |
| Florida Medical Clinic LLC | Mark Eisner | United States | Florida | Zephyrhills |
| SIH Research, LLC | Syed Mumtaz | United States | Florida | Kissimmee |
| Clintheory Healthcare | Souheil Moussly | United States | Florida | Orlando |
| Galen Medical Group | Colleen Schmitt | United States | Tennessee | Hixson |
| Direct Helpers Medical Center | Manuel Fernandez | United States | Florida | Hialeah |
| Digestive Health Specialists | William Holderman | United States | Washington | Tacoma |
| Delta Research Partners LLC | Bal Raj Bhandari | United States | Louisiana | Monroe |
| Mautalen Salud e Investigacion-Centro de Osteopatías Médicas | Emiliano Tron | Argentina | Buenos | Buenos |
| CER Instituto Medico | Edgardo Gimenez | Argentina | Buenos | Quilmes |
| Hospital Privado Centro Medico de Cordoba SA | Domingo Balderramo | Argentina | Cordoba | Cordoba |
| Fundación de Estudios Clínicos | Camilo Azum | Argentina | Santa Fe | Rosario |
| Centro de Investigaciones Metabólicas (CINME) | Estanislao Gomez | Argentina | CABA Buenos Aires | CABA Buenos Aires |
| Sanatorio 9 de Julio SA | Abel Novillo | Argentina | Tucuman | San Miguel de Tucuman |
| Centro de Investigaciones Médica Tucumán | Eduardo Ezequiel Martinez | Argentina | Tucumán | SAN M. DE TUCUMAN |
| Coastal Digestive Health | Hans Seltenreich | Australia | Queensland | Maroochydore |
| Royal Adelaide Hospital | Peter Bampton | Australia | South Australia | Adelaide |
| The Alfred Hospital | Miles Sparrow | Australia | Victoria | Melbourne |
| The Royal Melbourne Hospital Colorectal Medicine & Genetics, | Finlay Macrae | Australia | Victoria | Parkville |
| Box Hill Hospital | Olga Niewiadomski | Australia | Victoria | Box Hill |
| Princess Alexandra Hospital | Gerald Holtmann | Australia | Queensland | Brisbane |
| Mater University Hospital | Jakob Begun | Australia | Queensland | South Brisbane |
| M S Ramaiah Medical College Hospital | Avinash Balekuduru | India | Karnataka | Bangalore |
| Fortis Hospital | Ajay Bhalla | India | Uttar Pradesh | Noida |
| Apollo Research and Innovations, Apollo Hospitals International Ltd | Shravan Bohra | India | Gujarat | Gandhinagar |
| King George Medical University | Abhijit Chandra | India | Uttar Pradesh | Lucknow |
| Centre for Liver Research & Diagnostics, Deccan College of Medical Sciences, Owaisi Hospital & Research Centre | Mohammed Aejaz Habeeb | India | Andhra Pradesh | Hyderabad |
| Bangalore Medical College and Research Institute | Parvesh Kumar Jain | India | Karnataka | Bangalore |
| S.R. Kalla Hospital | Mukesh Kalla | India | Rajasthan | Jaipur |
| Datta Meghe Institute of Medical Sciences (DU), Acharya Vinoba Bhave Rural Hospital | Vijendra Kirnake | India | Maharashtra | Wardha |
| Escorts Heart Institute and Research Centre Ltd | Ajay Kumar | India | Delhi | New Delhi |
| Shree Giriraj Hospital | Chetan Mehta | India | Gujarat | Rajkot |
| Midas Multispecilaity Hopsital Pvt Ltd | Shrikant Mukewar | India | Nagpur | Ramdaspeth |
| Poona Medical Foundation. Ruby Hall Clinic | Nitin Pai | India | Maharashtra | Pune |
| Nirmal Hospital Private Limited | Saumin Shah | India | Gujarat | Surat |
| Dayanand Medical College | Ajit Sood | India | Punjab | Ludhiana |
| Gandhi Hospital | Shravan Porika | India | Telangana | Secunderabad |
| Soroka Medical Center - Pediatric Outpatient Clinic | Arik Segal | Israel | Beer-Sheva | Beer-Sheva |
| Tel Aviv Sourasky Medical Center | Sigal Fishman | Israel | Tel Aviv | Tel Aviv |
| Assaf Harofeh Medical Center | Haim Shirin | Israel | Zerifin | Zerifin |
| Galilee Medical Center Department of Internal Medicine A | Assy Nimer | Israel | Haifa | Nahariya |
| Shaare Zedek Medical Center | Eran Goldin | Israel | Jerusalem | Bait Vagan Jerusalem |
| Kaplan Medical Center | Ehud Melzer | Israel | Rehovot | Rehovot |
| Kumagaya General Hospital | Takeshi Ishikawa | Japan | Saitama-Ken | Kumagaya-shi |
| Takagi Clinic | Sho Takagi | Japan | Miyagi-Ken | Sendai-shi |
| Kitakyushu Municipal Medical Center | Hirotada Akiho | Japan | Fukoka | Kitakyusyu-shi |
| Tokushukai Sapporo Higashi Tokushukai Hospital | Atsuo Maemoto | Japan | Hokkaido | Sapporo-shi |
| Juntendo University Hospital | Tomoyoshi Shibuya | Japan | Tokyo | Bunkyo-ku |
| Aichi Medical University Hospital | Makoto Sasaki | Japan | Aichi-ken | Nagakute-shi |
| Tokushukai Sapporo Tokushukai Hospital | Toshifumi Ashida | Japan | Hokkaido | Sapporo-shi |
| Kagawa Prefectural Central Hospital | Tomoki Inaba | Japan | Kagawa | Takamatsu |
| NHO Mito Medical Center | Hiroyasu Ishida | Japan | HigaShiibaraki-Gun | Ibaraki-machi |
| Ishida Clinic of IBD and Gastroenterology | Tetsuya Ishida | Japan | Oita-Ken | Oita-shi |
| NHO Hirosaki National Hospital | Yo Ishiguro | Japan | Aomori-Ken | Hirosaki-shi |
| Fukuoka University Chikushi Hospital | Takashi Hisabe | Japan | Fukuoka-Ken | Chikushino-shi |
| Kitasato University Kitasato Institute Hospital | Masaru Nakano | Japan | Tokyo | Minato-Ku |
| Okayama University Hospital | Sakiko Hiraoka | Japan | Okayama | Okayama |
| Fujita Health University Hospital | Naoki Ohmiya | Japan | Aichi-ken | Toyoake-shi |
| Shinseikai Sai Gastroenterology, proctology | Souken Sai | Japan | Osaka Fu | Fujiidera-shi |
| NHO Kyoto Medical Center | Shinji Katsushima | Japan | Kyoto | Kyoto-shi |
| NHO Osaka National Hospital | Hisashi Ishida | Japan | Osaka | Osaka-shi |
| Center Hospital of the National Center for Global Health and Medicine | Junichi Akiyama | Japan | Tokyo-To | Shinjuku-ku |
| Sankikai Yokohama Shin midori General Hospital | Nobutsuna Kuwamoto | Japan | Kanagawa-Ken | Yokohama-shi |
| Fukuoka University Hospital | Fumihito Hirai | Japan | Fukuoka | Fukuoka |
| Matsuaikai Matsuda Hospital | Kazuhiko Kawakami | Japan | Shizuoka-Ken | Hamamatsu-shi |
| Tokitokai Tokito Clinic | Satoki Tokito | Japan | Saitama-Ken | Saitama-shi |
| Showa University Koto Toyosu Hospital | Naoyuki Uragami | Japan | Tokyo | Koto-ku |
| Nagaoka Chuo General Hospital | Takashi Tomidokoro | Japan | Niigata | Nagaoka-shi |
| Aoyama Clinic GI Endoscopy & IBD Center | Nobuo Aoyama | Japan | Hyogo-Ken | Kobe-shi |
| Hiroshima University Hospital | Shinji Tanaka | Japan | Hiroshima-ken | Hiroshima-shi |
| Yokohama City University Medical Center | Reiko Kunisaki | Japan | Kanagawa | Yokohama |
| Hidaka Coloproctology Clinic | Hisamitsu Hidaka | Japan | Fukuoka-Ken | Kurume-shi |
| Jichi Medical University Hospital | Keijiro Sunada | Japan | Tochigi-Ken | Shimotsuke-shi |
| Showa University Northern Yokohama Hospital | Noriyuki Ogata | Japan | Kanagawa | Yokohama |
| Gunma University Hosptial | Toshio Uraoka | Japan | Gunma | Maebashi |
| Kumamoto University Hospital | Hideaki Naoe | Japan | Kumamoto | Kumamoto-shi |
| Mitsui Memorial Hospital | Nobuo Toda | Japan | Tokyo-To | Chiyoda-ku |
| Asahikawa City Hospital | Masaki Taruishi | Japan | Hokkaido | Asahikawa |
| Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital | Satoshi Motoya | Japan | Hokkaido | Sapporo-shi |
| Saga-Ken Medical Center Koseikan | Shinichi Ogata | Japan | Saga-Ken | Saga-Shi |
| Toho University School of Medicine, Sakura Hospital | Katsuyoshi Matsuoka | Japan | Chiba | Sakura |
| Tokyo Medical And Dental University Medical Hospital | Toshimitsu Fujii | Japan | Tokyo | Bunkyō |
| JHCO Tokyo Yamate Medical Center | Naoki Yoshimura | Japan | Tokyo | Shinjuku-ku |
| Kinshukai Infusion Clinic | Hiroaki Ito | Japan | Osaka-fu | Osaka-City |
| Kyorin University Hospital | Tadakazu Hisamatsu | Japan | Tokyo | Mitaka |
| Gokeikai Ofuna Chuo Hospital | Yutaka Endo | Japan | Kanagawa | Kamakura-shi |
| Toyama Prefectural Central Hospital | Koichiro Matsuda | Japan | Toyama | Toyama-Shi |
| Mie University Hospital | Noriyuki Horiki | Japan | Mie | Tsu |
| Sameshima Hospital | Yukinori Sameshima | Japan | Kagoshima | Kagoshima-shi |
| Takasaki General Medical Center | Tomohiro Kudo | Japan | Gunma | Takasaki |
| Kawasaki Municipal Kawasaki Hospital | Hanae Takagi | Japan | Kanagawa | Kawasaki |
| Dong-A University Hospital | Jonghun Lee | Korea, South | Busan Pusan | Kwangyǒkshi |
| Kangbuk Samsung Hospital | Dong II Park | Korea, South | Seoul | Seoul-teukbyeolsi |
| Asan Medical Center | Sang Hyoung Park | Korea, South | Seoul Korea | Songpa-Gu |
| Samsung Medical Center | YoungHo Kim | Korea, South | Seoul | Seoul-teukbyeolsi |
| Severance Hospital | Hyun-Soo Kim | Korea, South | Wonju-si | Gangwon-do |
| Kyung Hee University Hospital | Hyo-Jong Kim | Korea, South | Seoul Korea | Dongdaemun-gu Seoul Korea |
| Inje University Haeundae Paik Hospital | Tae-oh Kim | Korea, South | Busan | Busan |
| The Catholic University of Daejeon St. Mary's Hospital | Sang Bum Kang | Korea, South | Daejeon | Daejeon |
| Yeungnam Univeristy Medical Center | ByungIk Jang | Korea, South | Daegu | Daegu |
| University Malaya Medical Centre | Ida Normiha Hilmi | Malaysia | Kuala Lumpur | Lembah Pantai |
| Hospital Ampang | Rosaida Hj Md Said | Malaysia | Selangor | Ampang |
| Universiti Sains Malaysia | Yeong Yeh Lee | Malaysia | Kelantan | Kubang Kerian |
| Centro de Investigación Clínica Acelerada | Emilio Fernando Bermudez Villegas | Mexico | Mexico City Distrito Federal | Mexico City Distrito Federal |
| Investigación Biomédica para el Desarrollo de Fármacos S.A. de C.V. | Roberto Cruz Neri | Mexico | Jalisco | Zapopan |
| Sociedad de Metabolismo y Corazon S.C. | Aracely Cruz Palacios | Mexico | Veracruz | Veracruz |
| Centro Para el Desarrollo de la Medicina y de Asistencia Med | Victor Efren Gallardo Angulo | Mexico | Sinaloa | Culiacan |
| Scientia Investigacion Clinica S.C. | Gaspar Iglesias Miramontes | Mexico | Chihuahua | Chihuahua |
| LLC Scientific Research Centre EKO-Bezopasnost | Konstantin Zakharov | Russian Federation | Saint Petersburg | Saint Petersburg |
| Yaroslavl Municipal HI Clinical Hospital #8 | Andrey Arshinov | Russian Federation | Yaroslavl | Yaroslavl |
| Saint Petersburg State Medical University n.a. Pavlov I.P. | Vasiliy Trofimov | Russian Federation | Saint Petersburg | Saint Petersburg |
| Clinical Diagnostic Center Ultramed | Valentina Molostova | Russian Federation | Omsk | Omsk |
| Pokrovskaya Municipal Hospital | Igor Bakulin | Russian Federation | Saint-Petersburg | Saint-Petersburg |
| Private Healthcare Institution Clinical Hospital Russian Railways - Medicine of Nizhniy Novgorod | Natalia Eremina | Russian Federation | Volga Federal | Nizhniy Novgorod |
| Karelia Republican Hospital V.A. Baranova | Olga Barysheva | Russian Federation | Petrozavodsk | Petrozavodsk |
| City Mariinskaya Hospital | Natalia Gonchar | Russian Federation | St. Petersburg | St. Petersburg |
| Medical rehabilitation center | Nikitin Igor | Russian Federation | Moscow | Moscow |
| Non-state Healthcare Institution | Viktor Shunkov | Russian Federation | Saint-Petersburg | Saint-Petersburg |
| State Autonomous Institution of Healthcare | Rustem Abdulkhakov | Russian Federation | Kazan | Kazan |
| Medical Institute REAVIZ | Elena Bunkova | Russian Federation | Samara | Samara |
| Clinical Trials Center of Medical Institute | Vladimir Rafalskiy | Russian Federation | Kaliningrad | Kaliningrad |
| SIH Kemerovo Regional Clinical Hosptial | Irina Khodareva | Russian Federation | Kemerovo | Kemerovo |
| Multidisciplinary Medical Clinic | Galina Chumakova | Russian Federation | Barnaul | Barnaul |
| SBIH City Clinical Hospital #31 | Oksana Shchukina | Russian Federation | Saint-Petersburg | Saint-Petersburg |
| LLC MA New Hospital | Denis Nikolin | Russian Federation | Ekaterinburg | Ekaterinburg |
| Medical and Sanitary Division of Severstal | Denis Medvedev | Russian Federation | Cherepovets | Cherepovets |
| Stavropol State Medical Academy | Vladimir Pavlenko | Russian Federation | Stavropol | Stavropol |
| Irkutsk State Medical Academy of Continuing Education | Olga Fedorishina | Russian Federation | Irkutsk | Irkutsk |
| Rostov State Medical University | Alexey Yakovlev | Russian Federation | Rostov-on-Don | Rostov-on-Don |
| LLC “Medicine Center SibNovoMed | Marina Osipenko | Russian Federation | Novosibirsk | Novosibirsk |
| Nizhegorodskiy Regional Clinical Hospital N.A.Semashko | Olga Alexeeva | Russian Federation | Novgorod | Novgorod |
| LLC Alliance Biomedical - Ural Group | Liudmila Odnopozova | Russian Federation | Izhevsk | Izhevsk |
| LLC Novosibirsk GastroCenter | Ekaterina Valuyskikh | Russian Federation | Novosibirsk | Novosibirsk |
| Clinical Center Bezanijska Kosa | Slobodanka Crevar-Marinovic | Serbia | Belgrade NAP | Belgrade NAP |
| General Hospital Dr Radivoj Simonovic | Mileva Lovric Jovanovic | Serbia | Sombor | Sombor |
| General Hospital Sremska Mitrovica | Gordana Mitic | Serbia | Mitrovica | Sremska |
| General Hospital | Tatjana Latinovic Radakovic | Serbia | Zrenjanin | Zrenjanin |
| Clinical Center Zvezdara | Petar Svorcan | Serbia | Belgrade | Belgrade |
| Clinical Center Kragujevac Gastroenterohepatology Clinic | Natasa Zdravkovic Petrovic | Serbia | Kragujevac | Kragujevac |
| China Medical University Hospital | Jen-Wei Chou | 中国台湾 | 台湾 | 台中市 |
| Health management center | Chia-Hung Tu | 中国台湾 | 台湾 | 台北 |
| Mersin University Medical Faculty | Engin Altintas | Turkey | Mersin | Yeni？ehir |
| Antalya Training and Research Hospital | Ayhan Cekin | Turkey | Antayla | Muratpasa |
| Kocaeli University Medical Faculty Hospital | Sadettin Hulagu | Turkey | Kocaeli | Izmit |
| Ege University Medicine of Faculty | Omer Ozutemiz | Turkey | Turkey | Izmir |
| Acibadem Universitesi - Acibadem Kozyatagi Hastanesi | Can Gonen | Turkey | Istanbul | Kad？koy |
| Kyiv Municipal Clinical Hospital #1 | Inna Markevych | Ukraine | Kyiv | Kyiv |
| Communal Institution | Igor Skrypnyk | Ukraine | Poltava | Poltava |
| Communal City Clinical Hospital of Ambulance | Valeriy Vdovychenko | Ukraine | Lviv | Lviv |
| Communal Enterprise | Olena Levchenko | Ukraine | Odesa | Odesa |
| Vinnytsia RCH of Veterans of War Dept of Therapy#1 Vinnytsia M.I.Pyrogov NMU | Valerii Ivanov | Ukraine | Vinnytsia | Vinnytsia |
| Communal institution of the Kyiv Regional Council “Kyiv Regional Clinical Oncology Dispensary” | Tetiana Lohdanidi | Ukraine | Kyiv | Kyiv |
| Communal Non-Commercial Enterprise of Lviv Regional Council Lviv Regional Clinical Hospital | Yaroslav Zborivskyy | Ukraine | Liviv | Liviv |
| Medical Centre CONSILIUM MEDICAL | Oksana Gerasymenko | Ukraine | Kyiv | Kyiv |
| Communal Institution of Kyiv Regional Council Kyiv Regional Hospital #2 | Viacheslav Neshta | Ukraine | Zaporizhzhia | Zaporizhzhia |
| DIASERVIS LTD | Oleksandr Oliinyk | Ukraine | Zaporizhzhia | Zaporizhzhia |
| MCIC MC LLC Health Clinic | Oleksandr Golovchenko | Ukraine | Ukraine | Vinnytsia |
| CHI Prof.O.O.Shalimov Kharkiv City Clinical Hospital #2 | Oleksii Datsenko | Ukraine | Kharkiv | Kharkiv |
| GI L.T. Malaya TI Namsu | Galyna Fadieienko | Ukraine | Kharkiv | Kharkiv |
| A. Novak Transcarpathian Regional Clinical Hospital | Iaroslava Rishko | Ukraine | Uzhgorod | Uzhgorod |
| Kharkiv City Student Hospital | Oleksii Oparin | Ukraine | Kharkiv | Kharkiv |
| Treatment-Diagnostic Center of Private Enterprise of PPC Atsynus | Viktorya Shevchuk | Ukraine | Kropyvnytskyi | Kropyvnytskyi |
| CI Kherson CCH | Alla Malytska | Ukraine | Kherson | Kherson |
| Lviv Clinical Hospital at Railway Transport of Division Healthcare Center PJSC Ukrainian Railway Sta | Olha Ivanishyn | Ukraine | Lviv | Lviv |
| CCH #1 Vinnytsia M.I. Pyrogov NMU Ch of Propaedeutics of IM | Halyna Tomashkevych | Ukraine | Vinnytsia | Vinnytsia |
| Ivano-Frankivsk Regional Clinical Hospital | Vira Vyshyvaniuk | Ukraine | Ivano-Frankivsk | Ivano-Frankivsk |
| M.I. Pyrogov Regional Clinical Hospital | Mykola Stanislavchuk | Ukraine | Vinnytsya | Vinnytsya |
| Communal institution of the Kyiv Regional Council “Kyiv Regional Clinical Oncology Dispensary” | Svitlana Danyliuk | Ukraine | Ukraine | Kyiv |
伦理委员会信息
| 名称 | 审查结论 | 审查日期 |
|---|---|---|
| 上海交通大学医学院附属仁济医院 | 同意 | 2019-09-03 |
| 上海交通大学医学院附属仁济医院医学伦理委员会 | 同意 | 2019-09-03 |
| 上海交通大学医学院附属仁济医院医学伦理委员会 | 同意 | 2020-04-01 |
| 上海交通大学医学院附属仁济医院医学伦理委员会 | 同意 | 2020-11-19 |
| 上海交通大学医学院附属仁济医院医学伦理委员会 | 同意 | 2021-05-06 |
| 上海交通大学医学院附属仁济医院医学伦理委员会 | 同意 | 2021-07-05 |
| 上海交通大学医学院附属仁济医院医学伦理委员会 | 同意 | 2021-11-03 |
| 上海交通大学医学院附属仁济医院医学伦理委员会 | 同意 | 2023-02-01 |
| 上海交通大学医学院附属仁济医院医学伦理委员会 | 同意 | 2023-11-29 |
试验状态信息
试验状态
进行中-招募完成
目标入组人数
国内: 65 ；
国际: 1044 ；
已入组例数
国内: 166 ；
国际: 登记人暂未填写该信息；
实际入组总例数
国内: 登记人暂未填写该信息；
国际: 登记人暂未填写该信息；
第一例受试者签署知情同意书日期
国内：2020-07-21；
国际：2018-10-19；
第一例受试者入组日期
国内：2020-08-21；
国际：登记人暂未填写该信息；
试验终止日期
国内：登记人暂未填写该信息；
国际：登记人暂未填写该信息；
临床试验结果摘要
| 版本号 | 版本日期 |
|---|
